You'll want to keep track over the season, make transfers, make subs as some players have a tough game and you don't expect them to score points, etc.
It's the way you have to keep up with it that makes the PL season a little more interesting, as you try to figure out which players are going to perform well and are good 'value'.
I believe you can make free transfers up until the first game, then they cost you points - outside that one free transfer per week.
Pick your captain, too. They get double points. I usually went with Haaland last season. You can change this game to game.